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Collagen Basic Structure

collagen basic structure

The  basic structural unit of collagen is the tropocollagen. The procollagen  peptide has a primary structure with (Gly-xy) n repeats, where x is  usually proline (Pro) and y is hydroxyproline Hypro) or Hydroxylysine (Hylys). The  glycosylation of Hylys residues occurs with a galactose residue (Gal)  but usually Glu-Gal-. The amount of sugar on the collagen is about 10%  of the collagen. The procollagen is a fibrous protein composed of three α-peptide  chains, mutually twisted into three strands of helical configuration  with a length of 300 nm and a diameter of 1.5 nm.
So far, about 20 genes have been found to encode different types of  collagen in different tissues. Different types of collagen are located  in specific tissues in the body. There are also 2-3 different types of  collagen present in the same tissue.
Similarities and Differences of Collagen, Gelatin and Collagen
Collagen  is translated into collagen (protein), commonly known as collagen, in  English-Chinese Chemistry and Chemical Vocabulary (3rd Edition, Science  Press, 1988), sometimes to account for the convenience of injury or to  emphasize the properties of the protein. Collgagen Make collagen. Collagen  is a type of protein that exists in animal tissues and organs. With the  different methods and conditions, collagen, gelatin and collagen can be  produced during the extraction and separation. What can be called collagen must be that type of protein whose triple  helix structure has not changed, yet retain its biological activity.
Gelatin is a denatured product of collagen under the action of acids,  bases, enzymes or high temperature. It consists of 18 amino acids, like  collagen, but has lost its biological activity.
The  first hydrolyzate of the collagen, collagen, is a triple-helix  structure of collagen that is loosened into three free peptide chains  and degraded into polydispersed segments, including small peptides. Therefore,  collagen is a mixture of peptides, the relative molecular mass from a  few thousand to tens of thousands, a wide distribution of molecular  weight, no biological activity, soluble in cold water, and can be  protease utilization. Collagen is extremely closely linked to the body's growth, aging and disease. Because  of its good biocompatibility, nutrition, repair, moisturizing,  compatibility and affinity, it is widely used in biomedical materials,  cosmetics, food and health products and other functional products. Collagen has beauty (anti-wrinkle, moisturizing, whitening, weight  loss, breast enhancement), prevention of osteoporosis, improve joint  health, improve blood circulation, stomach, improve human immunity and  other effects.
Through  the above description, can be summarized as follows: a collagen has  biological activity, do not dissolve in cold water and hot water, can  not be protease utilization; b gelatin relatively high molecular weight  only soluble in hot water, insoluble in cold water, collagen molecules Lower  quality, wider molecular weight distribution than gelatin, soluble in  cold water; c. Gelatin and collagen are biologically inactive but can be  utilized by proteases.

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